Structures and Hydrogen Bonding Recognition of Mefenamic Acid Form I Crystals in Mefenamic Acid/ Ethanol Solution
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چکیده
منابع مشابه
Mefenamic acid enteropathy.
The clinical, radiological, and histological features of two patients with severe intestinal damage induced by mefenamic acid and mimicking coeliac disease are described. Symptoms rapidly reverted on withdrawal of the drug, and in one case, did not relapse during treatment with other non-steroidal anti-inflammatory drugs.
متن کاملSpherical Crystallization of Mefenamic Acid
*To whom all correspondence should be addressed. he quality of a solid pharmaceutical preparation is influenced by primary micromeritic characteristics such as the shape and size of drug crystals, especially when large amounts of poorly soluble drugs are formulated. To improve the dissolution rate of poorly soluble drugs, fine crystals are preferred over large crystals because they provide a gr...
متن کاملMefenamic acid-induced bullous pemphigoid.
A 52 year old man developed bullous pemphigoid, Coombs' positive haemolytic anaemia and diarrhoea related to the use of mefenamic acid. Clinical manifestation of the bullous pemphigoid, haemolytic anaemia and diarrhoea resolved following discontinuation of the mefenamic acid. Mefenamic acid should be added to the list of agents that are known to induce bullous pemphigoid.
متن کاملAccessing Mefenamic Acid Form II through High-Pressure Recrystallisation
High-pressure crystallisation has been successfully used as an alternative technique to prepare Form II of a non-steroidal anti-inflammatory drug, mefenamic acid (MA). A single crystal of Form II, denoted as high-pressure Form II, was grown at 0.3 GPa from an ethanolic solution by using a diamond anvil cell. A comparison of the crystal structures shows that the efficient packing of molecules in...
متن کاملEnteritis and colitis associated with mefenamic acid.
Water intoxication causes hyponatraemia, which is responsible for the neurological dysfunction by causing intracellular overhydration. Symptoms may occur if the serum sodium concentration is less than 120 mmol/l, but the degree of brain dysfunction corresponds with the rapidity of development of the hyponatraemia. Intracellular potassium concentration is reduced, partly due to increased intrace...
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ژورنال
عنوان ژورنال: International Journal of Chemical Engineering and Applications
سال: 2013
ISSN: 2010-0221
DOI: 10.7763/ijcea.2013.v4.277